Pharmaceuticals for the treatment of central nervous system disorders; pharmaceuticals for the treatment of neurological and psychiatric disorders; pharmaceuticals for the treatment of agitation; pharmaceuticals for the treatment of agitation associated with neuropsychiatric conditions, neurodegenerative diseases, schizophrenia, bipolar disorder, dementia, delirium, alcohol withdrawal, opioid use disorder, opioid withdrawal, substance abuse withdrawal, depression or any other central nervous system disorder; pharmaceuticals for the treatment of symptoms associated with alcohol withdrawal, opioid use disorder, opioid withdrawal, substance abuse withdrawal, depression or other central nervous system disorders.