Pharmaceutical preparations for the treatment of brain disease using technology capable of passing through the blood-brain barrier (BBB) to deliver therapeutic proteins directly to brain tissue, using the DAT (dual action therapy) platform for medical purposes; pharmaceutical preparations for the treatment of Alzheimer's disease (senile dementia); pharmaceutical preparations for the treatment of brain disease for medical purposes; pharmaceutical preparations for the treatment of central nervous system [CNS] diseases; pharmaceutical preparations for the treatment of neurodegenerative brain diseases for medical purposes; pharmaceutical preparations for the treatment of Parkinson's disease.