Active chemical ingredients for use in the manufacture of pharmaceuticals for hormone replacement therapy and for treating diseases and disorders related to: the autoimmune system, cardiovascular system, central nervous system, endocrine system, gastrointestinal system, metabolic system, musculoskeletal system, neurological system, neuromuscular system, respiratory system, urogenital system, genetics, immunology, infections, inflammation, menopause, ophthalmology, psychiatry, urology, viruses, blood, liver, erectile dysfunction, sexual dysfunction, cancer, pain, diabetes, fungus, and dermatology