Medical apparatus and devices for use in treatment of benign and non-benign biological tissues; medical devices for use in treating skin conditions; medical devices, namely, medical pulse generators and pulse generator circuits for tissue modification, manipulation and/or ablation; medical apparatus designed for use with nanopulse electricity for manipulation, modification and/or ablation of biologic tissue; medical apparatus, devices and instruments utilizing electrical pulsing technology for prevention, detection, diagnosis and treatment of medical disease, injuries and conditions, such as tumors, skin and tissue disorders, warts, viruses, papillomas, and other tissue and skin growths; medical systems comprising medical devices in the nature of pulse generators, pulse generator circuits, medical probes, medical wands, medical electrodes and treatment tips for use in tissue modification, manipulation and /or ablation; medical and surgical devices, and medical systems and accessories comprised of skin marking tools, guides for placement of medical electrodes on lesions or tumors all for diagnosis and treatment of tissue and blood diseases, conditions and abnormalities; medical pulse generators and medical electrodes for nanosecond pulse delivery for treatment of medical conditions or cosmetic tissue defects; medical device accessories to enable treatment of biological tissues comprising one or more of the following: medical treatment tips, medical electrodes, electric medical connectors, medical handpieces, medical probes to access internal and external anatomical areas and coupling gels sold as a unit, and tissue marking tools