Pharmaceutical preparations, including pharmaceutical preparations for the treatment and prevention of lipoatrophy, lipodystrophy, hypothalamic amenorrhea, leptin deficiency, diabetes mellitus, hepatomegaly, hypertriglyceridemia, hypercholesterolemia, fatty liver disease including non-alcoholic fatty liver disease and non-alcoholic steatohepatitis, metabolic disorders, endocrine conditions and disorders, hormonal diseases and disorders, cardiovascular diseases and disorders, reproductive disorders