Pharmaceuticals for treatment and prevention of diseases and conditions in humans; pharmaceuticals for the treatment of erectile dysfunction and sexual dysfunctions and disorders in males and females, for the maintenance of sexual health, for treatment of menopause and post-menopause symptoms and conditions, for treatment of hormonal disorders, for use in the treatment and prevention of endometriosis, osteoporosis, urinary incontinence and infertility, for the treatment of obesity, to facilitate weight loss and weight control, to suppress appetite and lower the threshold for satiety, for treatment of metabolic disorders, for treatment of diabetes, cardiovascular disorders and cardiovascular diseases in humans, and for treatment of sleep disorders and neurodegenerative diseases; contraceptive preparations for use in humans